在线客服1号
Recombinant Human Interleukin-31 (E. coli) 重组人白介素-33（E. coli）
白细胞介素-33 (IL-33) 是一种促炎细胞因子，属于 IL-1 家族。IL-33 在多种细胞中表达，包括上皮细胞和内皮细胞、平滑肌细胞、巨噬细胞和成纤维细胞。IL-33 的主要受体是 ST2 和 IL-1 受体辅助蛋白 (IL-1RAcP)，IL-33 在损伤过程中由细胞分泌，诱导 T 辅助 2 型炎症反应。
生物活性
Human Interleukin-33 (IL-33) is a proinflammatory cytokine that belongs to the IL-1 family. IL-33 plays a role in autoimmune disease. IL-33’s interaction with ST2 can drive allergic pathology and IL-33 has been reported to play a role in the development of rheumatoid arthritis and systemic lupus erythematosus. IL-33 is expressed in a variety of cells, including epithelial and endothelial cells, smooth muscle cells, macrophages and fibroblasts. The primary receptors for IL-33 are ST2 and IL-1 receptor accessory protein (IL-1RAcP), both of which belong to the IL-1 receptor family. IL-33 is localized to the nucleus of resting cells where it binds to chromatin in the H2A-H2B histone complex as a transcriptional suppressor. IL-33 is secreted by cells during injury which induces a T-helper 2 type inflammatory response.
ED50 < 0.5 ng/ml, measured by a cell proliferation assay using D10S cells, corresponding to a specific activity of > 2.0 × 106 units/mg.
不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）
| 小鼠 | 大鼠 | 兔 | 豚鼠 | 仓鼠 | 狗 | |
| 重量 (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| 体表面积 (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km 系数 | 3 | 6 | 12 | 8 | 5 | 20 |
| 动物 A (mg/kg) = 动物 B (mg/kg) × | 动物 B的Km系数 |
| 动物 A的Km系数 |
例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。
化学数据
| 分子量 | |
| 分子式 | |
| CAS号 | |
| 纯度 | >95%, Endotoxin <0.2 EU/ug |
| 溶解性（25°C） | Reconstitute in ddH₂O up to 100 μg/ml |
| 储存和运输条件 | 固体粉末： -20°C 冷藏长期储存 常温运输及临时存放 |
仅供科研使用，不得用于临床检验及治疗使用！