APOC4 polyclonal antibody

Host: Rabbit  Reactivity: Human,Mouse

BackGround:Apolipoproteins are protein components of plasma lipoproteins(1). The apolipoprotein C gene family encodesfour homologous proteins designated apoC-I to -IV,which specifically modulate the metabolism of triglyceride-richlipoproteins (2). The human apoC-I gene maps tochromosome 19q13.2 and is expressed primarily in theliver where it is activated when monocytes differentiateinto macrophages (3,4). The human apoC-II gene maps tochromosome 19q13.2 and encodes a 79 amino acid singlechain protein that is a necessary cofactor for the activationof lipoprotein lipase, the enzyme that hydrolyzes triglyceridesin plasma and transfers the fatty acids to tissues(5–7). The human apoC-III gene maps to chromosome11q23 and encodes a protein that may delay catabolismof triglyceride-rich particles by inhibiting lipoproteinlipase and hepatic lipase (8). The human apoC-IV genemaps to chromosome 19q13.2 and encodes a 127 aminoacid protein that is primarily expressed in the liver (9,10).

Product:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide,50% glycerol, pH7.2

Molecular Weight:

~ 15 kDa

Swiss-Prot:

P55056

Purification&Purity:

The antibody was affinity-purified from rabbit antiserumby affinity-chromatography using epitope-specific immunogenand the purity is > 105% (by SDS-PAGE).

Applications:

WB: 1:500~1:1000

IHC: 1:50~1:200

Storage&Stability:

Store at 4°C short term. Aliquot and store at -30°C longterm. Avoid freeze-thaw cycles.

Specificity:

APOC4 polyclonal antibody detects endogenous levels ofAPOC4 protein.

DATA:

Note:

For research use only, not for use in diagnostic procedure.