ApoER2 polyclonal antibody

Host: Rabbit  Reactivity: Human,Mouse,Rat

BackGround:ApoER2 (apolipoprotein E receptor 2), also designatedLRP8, is a member of the LDL receptor gene family,which includes LDL receptor, LRP, megalin, VLDLR andApoER2. The LDL receptor family is characterized by acluster of cysteine-rich class A repeats, epidermal growthfactor (EGF)-like repeats, YWTD repeats and an O-linkedsugar domain. ApoER2 is expressed in brain and placentaand has several splice variants. ApoER2 is thought tomediate the interaction of extracellular Reelin and cytosolicmDab1 (mammalian disabled protein), which activatesa tyrosine kinase. This pathway regulates the migrationof neurons along the radial glial fiber network duringbrain development.

Product:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide,50% glycerol, pH7.2

Molecular Weight:

~ 126 kDa

Swiss-Prot:

Q14114

Purification&Purity:

The antibody was affinity-purified from rabbit antiserum

by affinity-chromatography using epitope-specific immunogenand the purity is > 95% (by SDS-PAGE).Applications:

WB: 1:500~1:1000

Storage&Stability:

Store at 4°C short term. Aliquot and store at -20°C longterm. Avoid freeze-thaw cycles.

Specificity:

ApoER2 polyclonal antibody detects endogenous levelsof ApoER2 protein.

DATA:

Note:

For research use only, not for use in diagnostic procedure.