SMC5 Polyclonal Antibody

Host: Rabbit   Reactivity:Human,Mouse,Rat,Dog,Rabbit,

BackGround:

Structural Maintenance of Chromosomes (SMC) familyproteins play critical roles in various nuclear events thatrequire structural changes of chromosomes, includingmitotic chromosome organization, DNA recombinationand repair and global transcriptional repression. Thechromosome proteins are conserved in eukaryotes lead tomitotic chromosome segregation defects, suggesting acritical function of SMC family proteins in mitotic chromosomedynamics.

Product:

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and50% Glycerol.

Molecular Weight:

145kDa

Swiss-Prot:

Q8IY18

Purification&Purity:

affinity purified by Protein A

Applications:

IHC-P=1:100-500

Storage&Stability:

Store at 4°C short term. Aliquot and store at -20°C longterm. Avoid freeze-thaw cycles.

Specificity:

SMC5 Polyclonal Antibody detects endogenous levelsof SMC5 protein.

DATA:

Note:

For research use only, not for use in diagnostic procedure.

LRRC48 is a 523 amino acid protein that contains fiveLRR (leucine-rich) repeats and one LRRCT domain. Existingas two alternatively spliced isoforms, LRRC48 isencoded by human chromosome 17p11.2.

In the process of endocytosis, essential rate-limiting regulatorof a fast recycling pathway back to the plasmamembrane. During cytokinesis, required for the postfurrowingterminal steps, namely for intercellular bridge stabilityand abscission, possibly by controlling phosphatidylinositol4,5-bis phosphate (PIP2) and SEPT2 localizationat the intercellular bridge.