JAK2 Polyclonal Antibody
Host: Rabbit Reactivity:Human,Mouse,Rat
BackGround:
JAK2 (Janus kinase 2) belongs to the emerging family ofnon-receptor Janus tyrosine kinases, which regulate aspectrum of cellular functions downstream of activatedcytokine receptors in the lympho-hematopoietic system.Immunological stimuli, such as interferons and cytokines,induce recruitment of Stat transcription factors to cytokinereceptor-associated JAK2. JAK2 then phosphorylatesproximal Stat factors, which subsequently dimerize,translocate to the nucleus and bind to cis elements upstreamof target gene promoters to regulate transcription.The canonical JAK/Stat pathway is integral to maintaininga normal immune system by stimulating proliferation,differentiation, survival and host resistance to pathogens.Altering JAK/Stat signaling to reduce cytokine inducedpro-inflammatory responses represents an attractive targetfor anti-inflammatory therapies.
Product:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide,50% glycerol, pH7.2
Molecular Weight:
~ 130 kDa
Swiss-Prot:
O60674
Purification&Purity:
The antibody was affinity-purified from rabbit antiserumby affinity-chromatography using epitope-specific immunogenand the purity is > 95% (by SDS-PAGE).
Applications:
WB:1:2000~1:5000
Storage&Stability:
Store at 4°C short term. Aliquot and store at -20°C longterm. Avoid freeze-thaw cycles.
Specificity:
JAK2 polyclonal antibody detects endogenous levels ofJAK2 protein.
DATA:
Note:
For research use only, not for use in diagnostic procedure