EIF2S3 Polyclonal Antibody
Host: Rabbit Reactivity:Human,Mouse,Rat
BackGround:
The protein encoded by this gene is the largest subunit ofa heterotrimeric GTP-binding protein involved in the recruitmentof methionyl-tRNA(i) to the 40 S ribosomalsubunit.
Product:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide,50% glycerol, pH7.2
Molecular Weight:
~ 51 kDa
Swiss-Prot:
P41091
Purification&Purity:
The antibody was affinity-purified from rabbit antiserumby affinity-chromatography using epitope-specific immunogenand the purity is > 95% (by SDS-PAGE).
Applications:
WB: 1:500~1:2000
IHC: 1:50 ~1:200
Storage&Stability:
Store at 4°C short term. Aliquot and store at -20°C longterm. Avoid freeze-thaw cycles.
Specificity:
EIF2S3 polyclonal antibody detects endogenous levels ofEIF2S3 protein.
DATA:
Note:
For research use only, not for use in diagnostic procedure.
The NF-κB/Rel transcription factors are present in thecytosol in an inactive state complexed with the inhibitoryIκB proteins. Activation occurs via phosphorylation ofIκBα at Ser32 and Ser36 followed by proteasome-mediateddegradation that results in the releaseand nuclear translocation of active NF-κB. IκBα phosphorylationand resulting Rel-dependent transcription areactivated by a highly diverse group of extracellular signalsincluding inflammatory cytokines, growth factors,and chemokines. Kinases that phosphorylate IκB at theseactivating sites have been identified. The regulation ofIκBβ and IκBε is similar to that of IκBα. However, thephosphorylation and ubiquitin-mediated degradation ofthese proteins occurs with much slower kinetics. IKKphosphorylation of IκBβ occurs at Ser19 and Ser23, whileIκBε can be phosphorylated at Ser18 and Ser22.
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