LRP6 Polyclonal Antibody
Host: Rabbit Reactivity:Human,Mouse,Rat
BackGround:
This gene encodes a member of the low density lipoprotein(LDL) receptor gene family. LDL receptors aretransmembrane cell surface proteins involved in receptor-mediatedendocytosis of lipoprotein and protein ligands.The protein encoded by this gene functions as a receptoror, with Frizzled, a co-receptor for Wnt and therebytransmits the canonical Wnt/beta-catenin signalingcascade. Through its interaction with theWnt/beta-catenin signaling cascade this gene plays a rolein the regulation of cell differentiation, proliferation, andmigration and the development of many cancer types.This protein undergoes gamma-secretase dependent RIP(regulatedintramembrane proteolysis) processing but theprecise locations of the cleavage sites have not been determined.
Product:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide,50% glycerol, pH7.2
Molecular Weight:
~ 170 kDa
Swiss-Prot:
O75581
Purification&Purity:
The antibody was affinity-purified from rabbit antiserumby affinity-chromatography using epitope-specific immunogenand the purity is > 95% (by SDS-PAGE).
Applications:
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
Storage&Stability:
Store at 4°C short term. Aliquot and store at -20°C longterm. Avoid freeze-thaw cycles.
Specificity:
LRP6 polyclonal antibody detects endogenous levels ofLRP6 protein.
DATA:
Note:
For research use only, not for use in diagnostic procedure.