TBRG4 Polyclonal Antibody

Host: Rabbit   Reactivity:Human,Mouse,Rat

BackGround:

TBRG4 (transforming growth factor b regulator 4), alsoknown as CPR2 (cell cycle progression restoration protein2) or FASTKD4 (FAST kinase domaincontainingprotein 4), is a 631 amino acid protein that contains oneRAP domain and belongs to the FAST kinase family.TBRG4 is ubiquitously expressed and may have a role incell cycle progression. Existing as two alternativelyspliced isoforms, the gene encoding TBRG4 maps to humanchromosome 7p13. Chromosome 7 is approximately158 million bases long, encodes over 1,000 genes andmakes up about 5% of the human genome. Chromosome7 has been linked to Osteogenesis imperfecta, Pendredsyndrome, Lissencephaly, Citrullinemia and Shwachman-Diamondsyndrome. The deletion of a portion of theq arm of chromosome 7 is associated with Williams-Beurensyndrome, a condition characterized bymild mental retardation, an unusual comfort and friendlinesswith strangers and an elfin appearance. Deletions ofportions of the q arm of chromosome 7 are also seen in anumber of myeloid disorders including cases of acutemyelogenous leukemia and myelodysplasia.

Product:

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Molecular Weight:

~ 80 kDa

Swiss-Prot:

Q969Z0

Purification&Purity:

The antibody was affinity-purified from rabbit antiserumby affinity-chromatography using epitope-specific immunogenand the purity is > 95% (by SDS-PAGE).

Applications:

WB: 1:500 - 1:2000

IF: 1:50 - 1:200

Storage&Stability:

Store at 4°C short term. Aliquot and store at -20°C longterm. Avoid freeze-thaw cycles.

Specificity:

TBRG4 polyclonal antibody detects endogenous levels ofTBRG4 protein.

DATA:

Note:

For research use only, not for use in diagnostic procedure.

The NF-κB/Rel transcription factors are present in thecytosol in an inactive state complexed with the inhibitoryIκB proteins. Activation occurs via phosphorylation ofIκBα at Ser32 and Ser36 followed by proteasome-mediateddegradation that results in the releaseand nuclear translocation of active NF-κB. IκBα phosphorylationand resulting Rel-dependent transcription areactivated by a highly diverse group of extracellular signalsincluding inflammatory cytokines, growth factors,and chemokines. Kinases that phosphorylate IκB at theseactivating sites have been identified. The regulation ofIκBβ and IκBε is similar to that of IκBα. However, thephosphorylation and ubiquitin-mediated degradation ofthese proteins occurs with much slower kinetics. IKKphosphorylation of IκBβ occurs at Ser19 and Ser23, whileIκBε can be phosphorylated at Ser18 and Ser22.