RRM1 polyclonal antibody
Host: Rabbit Reactivity:Human,Mouse
BackGround:
Provides the precursors necessary for DNA synthesis.Catalyzes the biosynthesis of deoxyribonucleotides fromthe corresponding ribonucleotides.Under complex allostericcontrol mediated by deoxynucleoside triphosphatesand ATP binding to separate specificity and activationsites on the M1 subunit. The type of nucleotide bound atthe specificity site determines substrate preference. Itseems probable that ATP makes the enzyme reduce CDPand UDP, dGTP favors ADP reduction and dTTP favorsGDP reduction. Stimulated by ATP and inhibited by dATPbinding to the activity site.
Product:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide,50% glycerol, pH7.2
Molecular Weight:
~ 90 kDa
Swiss-Prot:
P23921
Purification&Purity:
The antibody was affinity-purified from rabbit antiserumby affinity-chromatography using epitope-specific immunogenand the purity is > 95% (by SDS-PAGE).
Applications:
WB: 1:500~1:2000
IHC: 1:50~1:200
Storage&Stability:
Store at 4°C short term. Aliquot and store at -20°C longterm. Avoid freeze-thaw cycles.
Specificity:
RRM1 polyclonal antibody detects endogenous levels ofRRM1 protein.
DATA:
Note:
For research use only, not for use in diagnostic procedure.