AR (phospho-S650) polyclonal antibody

Host: Rabbit   Reactivity: Human,Rat

BackGround:Androgens exhibit a wide range of effects on the development,maintenance and regulation of male phenotypeand reproductive physiology in males. The androgen receptor(AR) is a member of the steroid superfamily ofligand-dependent transcription factors. ARs bind activetestosterone (T) and dihydrotestosterone (DHT). The ratesof association and dissociation of T are about 3 timesmore rapid than those of DHT. This difference in bindingkinetics may account for the different physiological effectsof T and DHT. Androgen binding results in an atleast 6-fold increase in androgen receptor stability.

Product:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide,50% glycerol, pH7.2

Molecular Weight:

~ 110 kDa

Swiss-Prot:

P10275

Purification&Purity:

The antibody was affinity-purified from rabbit antiserumby affinity-chromatography using epitope-specific immunogenand the purity is > 95% (by SDS-PAGE).

Applications:

IHC: 1:50~1:200

Storage&Stability:

Store at 4°C short term. Aliquot and store at -20°C longterm. Avoid freeze-thaw cycles.

Specificity:

p-AR (S650) polyclonal antibody detects endogenouslevels of Androgen Receptor protein only when phosphorylatedat Ser650 .

DATA:

Note:

For research use only, not for use in diagnostic procedure