AR-β2 (phospho-S346) polyclonal antibody

Host: Rabbit   Reactivity: Human,Mouse,Rat

BackGround:Beta 2 Adrenergic Receptor is a member of the G protein-coupledreceptor superfamily. This receptor is directlyassociated with one of its ultimate effectors, theclass C L-type calcium channel Ca(V)1.2. This receptor-channelcomplex also contains a G protein, an adenylylcyclase, cAMP-dependent kinase, and the counterbalancingphosphatase, PP2A. The assembly of the signalingcomplex provides a mechanism that ensures specificand rapid signaling by this G protein-coupled receptor.This gene contains no introns in either its coding oruntranslated sequences. Different polymorphic forms,point mutations, and/or downregulation of this gene areassociated with nocturnal asthma, obesity and type 2 diabetes.Expression of the beta 2 Adrenergic Receptor hasbeen reported in adipose, blood, brain, heart, lung, nose,pancreas, skeletal muscle, skin, and vessel.

Product:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide,50% glycerol, pH7.2

Molecular Weight:

~ 47 kDa, 68 kDa (glycosylated), 95 kDa (Dimer)

Swiss-Prot:

P07550

Purification&Purity:

The antibody was affinity-purified from rabbit antiserumby affinity-chromatography using epitope-specific immunogen

and the purity is > 95% (by SDS-PAGE).

Applications:

WB: 1:500~1:1000

Storage&Stability:

Store at 4°C short term. Aliquot and store at -20°C longterm. Avoid freeze-thaw cycles.

Specificity:

p-AR-β2 (S346) polyclonal antibody detects endogenouslevels of AR-β2 protein only when phosphorylated at

Ser346.

DATA:

Note:

For research use only, not for use in diagnostic procedure.