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APP/β-Amyloid polyclonal antibody KL1418R

APP/β-Amyloid抗体

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¥ 1140.00 /支
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APP/β-Amyloid polyclonal antibody

Host: Rabbit  Reactivity: Human,Mouse,Rat

BackGround:Proteolytic cleavage of the Amyloid protein precursor(APP) gives rise to the β-Amyloid and Amyloid A4 proteins,which are present in human platelets. Amyloiddeposition is associated with type II diabetes, Down syndromeand a variety of neurological disorders, includingAlzheimer’s disease. The Amyloid precursor protein(APP) undergoes alternative splicing, resulting in severalisoforms. Proteolytic cleavage of APP leads to the formationof the Amyloid β/A4 Amyloid protein. This proteinis involved in the formation of neurofibrillary tanglesand plaques that characterize the senile plaques of Alzheimer’spatients. APLP1 (Amyloid precursor-like protein1) and APLP2 are structurally similar to APP. HumanAPLP2 is a membrane- bound sperm protein that containsa region highly homologous to the transmembrane-cytoplasmicdomains of APP found in brainplaques of Alzheimer’s disease patients.

Product:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide,

50% glycerol, pH7.2

Molecular Weight:

~ 110 kDa

Swiss-Prot:

P05067

Purification&Purity:

The antibody was affinity-purified from rabbit antiserumby affinity-chromatography using epitope-specific immunogenand the purity is > 95% (by SDS-PAGE).

Applications:

WB: 1:500~1:2000

IHC: 1:50~1:200

Storage&Stability:

Store at 4°C short term. Aliquot and store at -20°C longterm. Avoid freeze-thaw cycles.

Specificity:

APP/β-Amyloid polyclonal antibody detects endogenouslevels of Amyloid beta A4 protein.This antibody does notcross-react with other β-amyloid peptides.

DATA:

2021081909201548164

Note:

For research use only, not for use in diagnostic procedure.


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