APP/β-Amyloid polyclonal antibody
Host: Rabbit Reactivity: Human,Mouse,Rat
BackGround:Proteolytic cleavage of the Amyloid protein precursor(APP) gives rise to the β-Amyloid and Amyloid A4 proteins,which are present in human platelets. Amyloiddeposition is associated with type II diabetes, Down syndromeand a variety of neurological disorders, includingAlzheimer’s disease. The Amyloid precursor protein(APP) undergoes alternative splicing, resulting in severalisoforms. Proteolytic cleavage of APP leads to the formationof the Amyloid β/A4 Amyloid protein. This proteinis involved in the formation of neurofibrillary tanglesand plaques that characterize the senile plaques of Alzheimer’spatients. APLP1 (Amyloid precursor-like protein1) and APLP2 are structurally similar to APP. HumanAPLP2 is a membrane- bound sperm protein that containsa region highly homologous to the transmembrane-cytoplasmicdomains of APP found in brainplaques of Alzheimer’s disease patients.
Product:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide,
50% glycerol, pH7.2
Molecular Weight:
~ 110 kDa
Swiss-Prot:
P05067
Purification&Purity:
The antibody was affinity-purified from rabbit antiserumby affinity-chromatography using epitope-specific immunogenand the purity is > 95% (by SDS-PAGE).
Applications:
WB: 1:500~1:2000
IHC: 1:50~1:200
Storage&Stability:
Store at 4°C short term. Aliquot and store at -20°C longterm. Avoid freeze-thaw cycles.
Specificity:
APP/β-Amyloid polyclonal antibody detects endogenouslevels of Amyloid beta A4 protein.This antibody does notcross-react with other β-amyloid peptides.
DATA:
Note:
For research use only, not for use in diagnostic procedure.